https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Hyperprolactinemia in a male pituitary androgen receptor knockout mouse is associated with female-like lactotroph development https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51687 Wed 28 Feb 2024 10:32:44 AEDT ]]> Androgen receptor is dispensable for x-zone regression in the female adrenal but regulates post-partum corticosterone levels and protects cortex integrity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45206 Cyp11a1-Cre to specifically ablate AR from the mouse adrenal cortex. Results show that AR-signaling is dispensable for adrenal gland development in females, and for X-zone regression during pregnancy, but is required to suppress elevation of corticosterone levels post-partum. Additionally, following disruption to adrenal AR, aberrant spindle cell development is observed in young adult females. These results demonstrate sexually dimorphic regulation of the adrenal X-zone by AR and point to dysfunctional adrenal androgen signaling as a possible mechanism in the early development of adrenal spindle cell hyperplasia.]]> Wed 26 Oct 2022 17:41:19 AEDT ]]> Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45093 Wed 26 Oct 2022 12:23:52 AEDT ]]> A graphical and computational modeling platform for biological pathways https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34906 Wed 22 May 2019 12:36:44 AEST ]]> Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36888 Wed 15 Jul 2020 11:42:42 AEST ]]> Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30558 40% of publications that have used tamoxifen to generate conditional knockouts have not reported even the minimum appropriate controls. To highlight the importance of this issue, the present study investigated the long-term impacts of different doses of a single systemic tamoxifen injection on the testis and the wider endocrine system. We found that a single dose of tamoxifen less than 10% of the mean dose used for recombination induction, caused adverse effects to the testis and to the reproductive endocrine system that persisted long-term. These data raise significant concerns about the widespread use of tamoxifen induction of recombination, and highlight the importance of including appropriate controls in all pathophysiological studies using this means of induction.]]> Wed 11 Apr 2018 17:20:19 AEST ]]> Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36575 Tue 09 Jun 2020 11:47:41 AEST ]]> Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42758 Thu 01 Sep 2022 15:59:25 AEST ]]> Modelling steroidogenesis: a framework model to support hypothesis generation and testing across endocrine studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32813 Mon 23 Sep 2019 12:29:40 AEST ]]> Characterisation of a mural cell network in the murine pituitary gland https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38232 Mon 16 Aug 2021 16:57:47 AEST ]]>